Akademik Veri Yönetim Sistemi
ONKOLOGIA I RADIOTERAPIA, cilt.18, sa.1, ss.1-7, 2024 (Scopus)
ABSTRACTBackground: Glioblastoma Multiforme (GBM) is the most common type of
brain tumor and it is an aggressive form of adult brain cancer that is globally
fatal. Unfortunately, the poor prognosis of patients with glioblastoma and
current treatments do not appear to be very effective against glioblastoma as
the disease is still fatal. Our study aimed to explore new ways of diagnosing the
disease to develop a treatment for this deadly disease.
Method: This study included 40 individuals (20 glioblastoma multiforme 20
control groups). The blood samples were taken from the study groups, and
biochemical analysis was performed. The groups were then compared for
statistical significance.
Results: Our study aimed to determine the relationship between enzymes,
some parameters levels and glioblastoma multiforme. When compared to
the control group, the levels of GSH-Px, SOD, CAT, AChE, and BChE were
decreased in patients with GBM, and the levels of MDA caspase-3, BDNF,
TNF alfa, and 8-OHdG were increased.
Conclusion: The results noted here point out that Apoptosis, Cholinergic
System Enzymes, and BDNF are good and accurate markers in Glioblastoma
Multiforme to know of diagnosing the disease. Will make it possible to use
characteristics seen in glioblastoma multiforme as indicators for assessing
tumor aggressiveness, as well as to get a better understanding of Proteins that
are involved in apoptosis as well as anti-apoptotic proteins, allowing for the
creation of novel molecularly based treatments.
Keywords: antioxidant enzymes, brain tumor, glioblastoma multiforme,
cholinergic system enzymes