Cytoprotective effects of boric acid and coenzyme Q10 therapy on induced pulmonary fibrosis in response to intratracheal administration of bleomycin in rats


Oto G. , Ekin S. , Çelikezen F. Ç. , Yener Z. , Tanritanir P. , Özdemir H. , ...More

Fresenius Environmental Bulletin, vol.22, no.8 A, pp.2428-2434, 2013 (Journal Indexed in SCI Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 8 A
  • Publication Date: 2013
  • Title of Journal : Fresenius Environmental Bulletin
  • Page Numbers: pp.2428-2434
  • Keywords: Bleomycin, Boric acid, Coenzyme q10, Pulmonary fibrosis, Rat

Abstract

This study was designed to examine cytoprotective effects of boric acid and CoQ10 on a model of bleomycininduced lung fibrosis. A total of 32 female Wistar albino rats (200-250 g, n=8) were randomly divided into four groups (control, bleomycin, bleomycin + boric acid, and bleomycin + boric acid + CoQ10). Rats in the control group were given equal volumes of saline intratracheally. Lung fibrosis was induced by intratracheal administration of bleomycin hydrochloride (7.5 mg/kg in 0.9% NaCl) to rats under anaesthesia. In the treatment groups, the rats were treated with boric acid (10 mg/kg per day; perorally) and CoQ10 (4 mg/kg per day; intraperitoneally) for 30 days. All animals were sacrificed at the end of the experiment. The lung, liver, kidney, and spleen tissues were excised, taken for histopathological evaluation, and stored for the measurement of SOD and GSH-Px activities with trace element and minerals. As a result, boric acid and boric acid + CoQ 10 had preventive roles on bleomycin-induced lung fibrosis in rats.