Relapsed/refractory thrombotic thrombocytopenic purpura treated with N-acetylcysteine: a case report


Demircioglu S. , Ekinci O. , Doğan A. , Demir C.

SCOTTISH MEDICAL JOURNAL, cilt.63, ss.122-124, 2018 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 63 Konu: 4
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1177/0036933018775240
  • Dergi Adı: SCOTTISH MEDICAL JOURNAL
  • Sayfa Sayısı: ss.122-124

Özet

Thrombotic thrombocytopenic purpura is a rare condition that presents with microangiopathic haemolytic anaemia, thrombocytopaenia, fever, renal impairment and neurological symptoms. Plasma exchange is a lifesaving treatment for this condition. However, some cases may be non-responsive to plasma exchange, or loss of response may occur. Treatment options for refractory cases include high-dose corticosteroids, rituximab, vincristine, cyclophosphamide, splenectomy, bortezomib and N-acetylcysteine. We present a refractory case of thrombotic thrombocytopenic purpura responding to the last of these therapies.