Relapsed/refractory thrombotic thrombocytopenic purpura treated with N-acetylcysteine: a case report


Demircioglu S., Ekinci O., Doğan A., Demir C.

SCOTTISH MEDICAL JOURNAL, vol.63, no.4, pp.122-124, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 4
  • Publication Date: 2018
  • Doi Number: 10.1177/0036933018775240
  • Journal Name: SCOTTISH MEDICAL JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.122-124
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

Thrombotic thrombocytopenic purpura is a rare condition that presents with microangiopathic haemolytic anaemia, thrombocytopaenia, fever, renal impairment and neurological symptoms. Plasma exchange is a lifesaving treatment for this condition. However, some cases may be non-responsive to plasma exchange, or loss of response may occur. Treatment options for refractory cases include high-dose corticosteroids, rituximab, vincristine, cyclophosphamide, splenectomy, bortezomib and N-acetylcysteine. We present a refractory case of thrombotic thrombocytopenic purpura responding to the last of these therapies.