Relapsed/refractory thrombotic thrombocytopenic purpura treated with N-acetylcysteine: a case report
SCOTTISH MEDICAL JOURNAL, vol.63, no.4, pp.122-124, 2018 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 63 Issue: 4
- Publication Date: 2018
- Doi Number: 10.1177/0036933018775240
- Journal Name: SCOTTISH MEDICAL JOURNAL
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.122-124
- Van Yüzüncü Yıl University Affiliated: Yes
Abstract
Thrombotic thrombocytopenic purpura is a rare condition that presents with microangiopathic haemolytic anaemia, thrombocytopaenia, fever, renal impairment and neurological symptoms. Plasma exchange is a lifesaving treatment for this condition. However, some cases may be non-responsive to plasma exchange, or loss of response may occur. Treatment options for refractory cases include high-dose corticosteroids, rituximab, vincristine, cyclophosphamide, splenectomy, bortezomib and N-acetylcysteine. We present a refractory case of thrombotic thrombocytopenic purpura responding to the last of these therapies.