Relapsed/refractory thrombotic thrombocytopenic purpura treated with N-acetylcysteine: a case report

Demircioglu S., Ekinci O., Doğan A., Demir C.

SCOTTISH MEDICAL JOURNAL, cilt.63, sa.4, ss.122-124, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 63 Sayı: 4
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1177/0036933018775240
  • Dergi Adı: SCOTTISH MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.122-124
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

Thrombotic thrombocytopenic purpura is a rare condition that presents with microangiopathic haemolytic anaemia, thrombocytopaenia, fever, renal impairment and neurological symptoms. Plasma exchange is a lifesaving treatment for this condition. However, some cases may be non-responsive to plasma exchange, or loss of response may occur. Treatment options for refractory cases include high-dose corticosteroids, rituximab, vincristine, cyclophosphamide, splenectomy, bortezomib and N-acetylcysteine. We present a refractory case of thrombotic thrombocytopenic purpura responding to the last of these therapies.