Assessment of rewarding and reinforcing properties of biperiden in conditioned place preference in rats

Allahverdiyev O., Nurten A., Enginar N.

BEHAVIOURAL BRAIN RESEARCH, vol.225, no.2, pp.642-645, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 225 Issue: 2
  • Publication Date: 2011
  • Doi Number: 10.1016/j.bbr.2011.07.050
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.642-645
  • Van Yüzüncü Yıl University Affiliated: No


Biperiden is one of the most commonly abused anticholinergic drugs. This study assessed its motivational effects in the acquisition of conditioned place preference in rats. Biperiden neither produced place conditioning itself nor enhanced the rewarding effect of morphine. Furthermore, biperiden in combination with haloperidol also did not affect place preference. These findings suggest that biperiden seems devoid of abuse potential properties at least at the doses used. (C) 2011 Elsevier B.V. All rights reserved.