Mathematical chemistry is the area of research in mathematics, in which problems of chemistry are solved by utilizing techniques of mathematics. In mathematical chemistry, a number is assigned to molecular graph of compound called topological index (TI) which depends on the topology of compound and helps us in deciding properties of concerned compound. TIs usually depend on the degree of vertices in a graph, distances and spectrum, among which degree depending TIs are studied extensively in recent years and have led to huge applications in theoretical chemistry, drugs formulation and pharmacy. This paper aimed to compute some degree depending TIs of Hex board networks and line graph of hex board networks. The generalized first and second multiplicative Zagreb indices (ZIs), multiplicative version of Atomic bond connectivity index (ABC) and generalized multiplicative Geometric Arithmetic index (GA) of Hex board and the line graph of Hex board networks were computed in this study.