Effects of the Phosphodiesterase-5 (PDE-5) Inhibitors, Avanafil and Zaprinast, on Bone Remodeling and Oxidative Damage in a Rat Model of Glucocorticoid-Induced Osteoporosis

Huyut, Zübeyir; BAKAN, Nuri; YILDIRIM, Serkan; Alp, Hamit

doi:10.12659/msmbr.908504

Effects of the Phosphodiesterase-5 (PDE-5) Inhibitors, Avanafil and Zaprinast, on Bone Remodeling and Oxidative Damage in a Rat Model of Glucocorticoid-Induced Osteoporosis

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Huyut Z., BAKAN N., YILDIRIM S., Alp H. H.

MEDICAL SCIENCE MONITOR BASIC RESEARCH, vol.24, pp.47-58, 2018 (ESCI)

Publication Type: Article / Article
Volume: 24
Publication Date: 2018
Doi Number: 10.12659/msmbr.908504
Journal Name: MEDICAL SCIENCE MONITOR BASIC RESEARCH
Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
Page Numbers: pp.47-58
Van Yüzüncü Yıl University Affiliated: Yes

Abstract

Background: The aim of this study was to evaluate the effects of the phosphodiesterase-5 (PDE-5) inhibitors, zaprinast and avanafil, on NO signalling pathway, bone mineral density (BMD), epiphyseal bone width, bone marrow angiogenesis, and parameters of oxidative stress in a rat model of glucocorticoid-induced osteoporosis (GIOP).