The probability of gamma or X-ray interactions with important 14 antioxidants have been discussed for total photon interactions in the wide energy range of 1 keV-100 GeV using the WinXCOM code. The variations of mass attenuation coefficient (mu(rho)), effective atomic number (Z(eff)) and electron density (N-el) with photon energy were plotted for total photon interactions. It was found that the values of mu(rho), Z(eff) and N-el depend on the incoming photon energy and chemical compositions of antioxidant. The highest values of these parameters were found at a low-energy zone where the photoelectric effect is the dominant interaction process. When antioxidants were compared with each other, it was seen that Z(eff) has the highest values for Oenin chloride and Delphinidin chloride which contain the Cl element. This investigation is thought to be useful for medical applications where radiation exposure is present.