Comparison of telomere length and insulin-like growth factor-binding protein 7 promoter methylation between breast cancer tissues and adjacent normal tissues in Turkish women

Kaya, Zehra; AKKİPRİK, MUSTAFA; Karabulut, Sevgi; Peker, Irem; Amuran, Gokce; Ozmen, Tolga; Gulluoglu, Bahadir; KAYA, HANDAN; Ozer, Ayse

doi:10.1002/jcla.22083

Comparison of telomere length and insulin-like growth factor-binding protein 7 promoter methylation between breast cancer tissues and adjacent normal tissues in Turkish women

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Kaya Z., AKKİPRİK M., Karabulut S., Peker I., Amuran G. G., Ozmen T., ...More

JOURNAL OF CLINICAL LABORATORY ANALYSIS, vol.31, no.5, 2017 (SCI-Expanded)

Publication Type: Article / Article
Volume: 31 Issue: 5
Publication Date: 2017
Doi Number: 10.1002/jcla.22083
Journal Name: JOURNAL OF CLINICAL LABORATORY ANALYSIS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Van Yüzüncü Yıl University Affiliated: Yes

Abstract

BackgroundBoth insulin-like growth factor-binding protein 7 (IGFBP7) and telomere length (TL) are associated with proliferation and senescence of human breast cancer. This study assessed the clinical significance of both TL and IGFBP7 methylation status in breast cancer tissues compared with adjacent normal tissues. We also investigated whether IGFBP7 methylation status could be affecting TL.