Electroanalytical determination of salbutamol in pharmaceutical formulations using cathodically pretreated boron-doped diamond electrode

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Talay Pınar P., Ali H. S., Abdullah A. A., Yardım Y., Şentürk Z.

JOURNAL OF RESEARCH IN PHARMACY, cilt.22, sa.3, ss.460-468, 2018 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.12991/jrp.2018.88
  • Dergi Adı: JOURNAL OF RESEARCH IN PHARMACY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.460-468
  • Anahtar Kelimeler: Salbutamol, boron-doped diamond electrode, square-wave adsorptive stripping voltammetry, pharmaceutical formulations, VOLTAMMETRIC DETERMINATION, CAPILLARY-ELECTROPHORESIS, LIQUID-CHROMATOGRAPHY, GOLD NANOPARTICLES, TOXIC RACTOPAMINE, MASS-SPECTROMETRY, CARBON NANOTUBES, URINE SAMPLES, HUMAN PLASMA, HPLC
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

This paper examined for the first time the possibilities of the usage of the cathodically pretreated borondoped diamond (CPT-BDD) electrode for the redox behavior of salbutamol (SAL) using cyclic and adsorptive stripping voltammetry. The cyclic voltammograms showed an irreversible and adsorption-controlled oxidation peak at about +1.0 V in the Britton-Robinson (BR) buffer (pH 9.0) solution. Under the optimized experimental condition, using square-wave adsorptive stripping mode, the compound yielded a well-defined voltammetric response in BR buffer, pH 9.0 at +0.95 V (vs. Ag/AgCl) (after 30 s accumulation at an open circuit condition). A linear calibration graph was obtained in the concentration range of 4.15 to 83 mu g mL(-1) (1.73x10(-5) -3.47x10(-4) M). A detection limit of 1.21 mu g mL(-1) (5.06x10(-6) M) was observed. The suggested method was also applied to the determination of SAL in the drug formulations.