Treatment of brucellosis and liver toxicity

Mert D., Bora G., Akkoyunlu Y., Demirpençe Ö., Meral M.

HEALTHMED, vol.7, no.7, pp.2158-2164, 2013 (Peer-Reviewed Journal)

  • Publication Type: Article / Article
  • Volume: 7 Issue: 7
  • Publication Date: 2013
  • Journal Name: HEALTHMED
  • Journal Indexes: Index Copernicus
  • Page Numbers: pp.2158-2164
  • Van Yüzüncü Yıl University Affiliated: Yes


Brucellosis is an important public health problem world-wide, especially in developing countries. Besides hepatic involvement of the disease, hepatitis may ocur due to antimicrobial drugs. The aim of this study is to investigate the hepatotoxicity of the treatment regimens of brucellosis. Patients and methods: In this study, 126 cases diagnosed with brucellosis who admitted to the Department of the Infectious Diseases and Clinical Microbiology, from November 2010 to August 2011, were evaluated, treated and followed up for hepatoxicity, prospectively. Results: The coombs STA test was positive in 126 cases (100 %). Focal involvement was present in 27(21.4%) cases. The most frequent involvement was osteoarticular involvement observed in 22 cases (17.5%). Genitourinary system involvement was present in 3 patients (2.4%). Hepatic involvement was present in 2 patients (1.6%). Conclusion: Brucellosis may cause serious morbidity in humans and it continues to be a major health problem in Turkey.