Akademik Veri Yönetim Sistemi
Eastern Journal of Medicine, cilt.31, sa.2, ss.334-340, 2026 (Scopus, TRDizin)
Gastrointestinal anastomotic healing depends on collagen dynamics, microcirculation, and immune responses. The vagus nerve modulates these via the cholinergic anti-inflammatory pathway. This study evaluated the effects of truncal vagotomy on jejunal anastomotic healing in rats. Forty male Wistar Albino rats were divided into five groups: control, day 4 anastomosis, day 4 vagotomy + anastomosis, day 7 anastomosis, and day 7 vagotomy + anastomosis. Standard end-to-end jejunal anastomoses were performed; vagotomy groups underwent transection of anterior and posterior vagal trunks. Healing was assessed by bursting pressure (cm H₂ O) and tissue hydroxyproline (µg/mg). No mortality or macroscopic leakage occurred. Mean bursting pressures were 87.0 ± 4.75, 95.37 ± 7.72, 98.25 ± 9.37, 109.25 ± 12.66, and 123.37 ± 4.27 cm H₂ O in Groups I–V, with a significant increase in the 7-day vagotomy group (p < 0.001). Hydroxyproline levels were 0.512 ± 0.223, 0.539 ± 0.025, 0.549 ± 0.023, 0.539 ± 0.025, and 0.584 ± 0.023 µg/mg; Group V was significantly higher than Groups IV and III (p < 0.001 and p = 0.038). At day 4, bursting pressure increased without a parallel rise in hydroxyproline, whereas both parameters increased significantly at day 7. Truncal vagotomy enhanced jejunal anastomotic healing at day 7 by increasing collagen deposition and mechanical strength. Disruption of vagal tone appears to modulate inflammatory and fibroblastic responses, influencing the temporal pattern of healing. Further mechanistic and clinical studies are warranted.