© 2021, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.Multiple sclerosis is an autoimmune central nervous system disease characterized by inflammation, demyelination and axon damage. The aim of this study was to determine peripheral nerve involvement and related factors in patients wi th multiple sclerosis. In our study, 35 (70.0%) of the patients were suffering from Relapsing Remitting Multiple Sclerosis, and 15 (30.0%) of them had Secondary Progressive Multiple Sclerosis. The mean age of the symptom onset of the disease in patients was 30.44 ± 1.06 years, the mean score of the Multiple Sclerosis Disability Scale (EDDS) was 2.97 ± 2.58 points Polyneuropatia was detected in 12 (24.0%) patients. Polyneuropathy was detected in 3 patients (6.0%) in the contr ol group. In our study, peripheral nerve involvement was higher in male patients than female patients. There was a very strong positive correlation between the duration of disease development and the Extended Multiple Sclerosis Disability Scale scores. In the study, it was determined that multiple sclerosis was more commonly seen in women in accordance with the literature, and EDDS scores increased as the disease duration increased.