Sleep disorders in patients with myasthenia gravis based on antibody subtypes: a polysomnographic study
BMC Neurology, cilt.26, sa.1, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 26 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.1186/s12883-026-04881-x
- Dergi Adı: BMC Neurology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals
- Anahtar Kelimeler: Multiple sleep latency test, Muscle specific kinase antibody, Myasthenia gravis, Obstructive sleep apnea syndrome, Polysomnography, Sleep disorders
- Van Yüzüncü Yıl Üniversitesi Adresli: Evet
Özet
Background: Sleep-disordered breathing (SDB) is increasingly recognized in myasthenia gravis (MG), yet potential differences in sleep respiratory patterns between antibody-defined MG subtypes remain poorly understood. We aimed to evaluate sleep disorders and polysomnographic characteristics in patients with acetylcholine receptor antibody–positive (AChR-MG) and muscle-specific tyrosine kinase antibody–positive (MuSK-MG) generalized MG. Methods: Eighteen clinically stable MG patients (9 AChR-MG, 9 MuSK-MG) and 9 healthy controls underwent attended overnight polysomnography followed by the Multiple Sleep Latency Test (MSLT). Standardized sleep questionnaires and MG clinical scales were administered to assess sleep-related symptoms and disease severity. Results: Obstructive sleep apnea was detected in 89% of AChR-MG and 78% of MuSK-MG patients. Both MG subgroups showed significantly higher apnea–hypopnea index values compared with controls (p < 0.05). Although overall AHI severity did not differ significantly between antibody groups, distinct respiratory patterns were observed. Respiratory events clustered predominantly during REM sleep in AChR-MG, whereas MuSK-MG patients exhibited more frequent events during NREM or supine sleep. Conclusions: Sleep-disordered breathing appears to be common in MG, but polysomnographic patterns may differ according to antibody subtype. REM-predominant respiratory events in AChR-MG and NREM or positional predominance in MuSK-MG may reflect differences in muscle involvement between these subtypes. These findings suggest that antibody-specific mechanisms may influence nocturnal respiratory dysfunction in MG and highlight the importance of targeted sleep assessment in this population.