© 2023, The Author(s) under exclusive licence to Iranian Society of Environmentalists (IRSEN) and Science and Research Branch, Islamic Azad University.In this research, electrocoagulation-intensified peroxidation using an aluminum electrode was studied as a post-treatment method for poultry slaughterhouse wastewater (SWW) with 4 operational variables (pH, current density, contact time, and H2O2 dosage). Optimization was carried out using response surface methodology. Analysis of variance was used to analyze the experimental data, and a second-order model was created to test the effects of process parameters on treatment performance. The optimum conditions were chosen as follows: pH 5.83, 0.18 g/L H2O2 dosage, 58.60 min contact time, and current density of 4.21 mA/cm2. The compatibility of the predicted optimum conditions has been verified by experimental data. As a result of the experiments performed under optimum conditions, COD, TSS, and color removals were found to be 97.89%, 99.31%, and 98.56%, respectively. The difference between experimental and predicted values was found to be less than 0.86%. The final treated effluent met the discharge standards determined by the World Bank, EU, US, and Malaysian Department of Environment. Under optimum conditions, the cost of treating 1 cubic meter of SWW was calculated as 3.02 MYR ($ 0.68).