Slavery, which has been encountered in various forms for thousands of years and in almost all civilizations, goes back in a history until the beginning of humanity. Although it has been banned in almost every society with approaches in theological fields and various legal regulations throughout its change process, it has never disappeared and has continued its existence by changing its shape. Slavery, which dates back to the past as much as the history of humanity, was also applied to mostly black people, who were brought by ships with the discovery of America to the American continent, which is called the new world. Black people, brought from Africa in chains, exposed to all kinds of violence and living in the worst conditions, fought for the independence of America, while at the same time, they fought hard to get rid of slavery. The slavery period of the blacks, who made great contributions to the construction of America, left a trace with the pain it caused to people and has been the subject of many works and research studies in the field of literature. Harriet Beecher Stowe's Uncle Tom's Cabin is an important example in this regard. The abolitionist Stowe revealed the most brutal aspects of American slavery in her work. In particular, Stowe, in her work, emphasized the inhuman behavior during the slave trade, the family dramas experienced in the slave markets, the tortures of the slaves, and the great suffering of the enslaved people. With Stowe's stance against slavery, the strongest voice on behalf of the slave period, Blacks felt America as their own country and accelerated the struggle for independence and the abolition of slavery. This study will describe the striking and brutal aspects of slavery practice in America with the work of Uncle Tom's Cabin and will try to explain the fact of slavery.