Evaluate the effects of platelet rich plasma (PRP) and zinc oxide ointment on skin wound healing

Abdullah B. J. , Atasoy N. , Omer A. K.

ANNALS OF MEDICINE AND SURGERY, vol.37, pp.30-37, 2019 (Journal Indexed in ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37
  • Publication Date: 2019
  • Doi Number: 10.1016/j.amsu.2018.11.009
  • Page Numbers: pp.30-37


In this study efficiency of platelet rich plasma (PRP) and zinc oxide on full thickness wounds created on rabbits was researched. This study conducted on 24 New Zealand rabbits divided 2 groups. A circular of 1.5 x 1.5 cm (2.5 cm(2)) full thickness skin wound was created under the general anesthesia. 1 ml PRP (5.503106/mm(3)) was applied to the one of the wounds subcutaneously. To the other wound 1mm(3) zinc oxide ointment was applied once a day during the study. Wound contraction rates were measured, biopsy materials were collected and evaluated macroscopically and histopathologically postoperatively 3rd, 7th and 15th days. As a result it is determined that PRP and zinc oxide accelerated wound contraction rates between the groups were determined as 3rd day p = 0.007, 7th day p = 0.0002 and 15th day p = 0.002.