Synthesis and biological properties of novel 1-methyl-2-(2-(prop-2-yn-1-yloxy)benzylidene) hydrazine analogues

Kıvrak A., Yılmaz C., Konuş M., KOCA H., Aydemir S., OAGAZ J. A.

TURKISH JOURNAL OF CHEMISTRY, cilt.42, sa.2, ss.306-316, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.3906/kim-1701-42
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.306-316
  • Anahtar Kelimeler: Hydrazines, hydrazones, ABTS, antioxidant capacities, biological properties, IN-VITRO, ANTIMICROBIAL EVALUATION, ANTITUBERCULAR ACTIVITY, ANTIOXIDANT CAPACITY, FREE-RADICALS, DERIVATIVES, AGENTS, ALLYLATION, ANTICANCER, HYDRAZONES
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

1-Methyl-2-(2-(prop-2-yn-1-yloxy)benzylidene)hydrazine analogues were readily prepared in good yields by the reaction of 2-(prop-2-yn-1-yloxy)benzaldehydes and methyl hydrazine. The reaction tolerates a variety of substituents on the 2-hydroxybenzaldehyde to form nitro-, halo-, methoxy-, and naphthyl-substituted 1-methyl-2-(2-(prop-2-yn-1-yloxy)benzylidene)hydrazines. The in vitro antioxidant capacity measurements revealed that among all the analyzed hydrazine analogues that surpassed the Trolox standard, 1-(2-(but-3-ynyl)-5-nitrobenzylidene)-2-methylhydrazine had the maximum value, which was approximately 1.7 times that of Trolox.