Neuroprotective effects of erythropoietin against oxidant injury following brain irradiation: an experimental study


Ugurluer G., ÇEBİ A., Mert H., Mert N., Serin M., ERKAL H. Ş.

ARCHIVES OF MEDICAL SCIENCE, vol.12, no.6, pp.1348-1353, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 6
  • Publication Date: 2016
  • Doi Number: 10.5114/aoms.2016.58622
  • Journal Name: ARCHIVES OF MEDICAL SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1348-1353
  • Keywords: brain, irradiation, oxidant injury, neuroprotective effects, erythropoietin, CENTRAL-NERVOUS-SYSTEM, RECOMBINANT-HUMAN-ERYTHROPOIETIN, RADIATION-INDUCED APOPTOSIS, OXIDATIVE-STRESS, RAT, MECHANISMS, PROTECTION, TOXICITY, RADICALS
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

Introduction: Radiation therapy (RT) is a major treatment modality, and the central nervous system is a dose-limiting organ in clinical RT. This experimental study aims to present the evaluation of the neuroprotective effects of erythropoietin (EPO) against oxidant injury following brain irradiation in rats.