An easy synthetic protocol for imidazo-1,4-oxazines and evaluation of their toxicities
HETEROATOM CHEMISTRY, cilt.29, sa.1, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29 Sayı: 1
- Basım Tarihi: 2018
- Doi Numarası: 10.1002/hc.21412
- Dergi Adı: HETEROATOM CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Van Yüzüncü Yıl Üniversitesi Adresli: Evet
Özet
Imidazo-1,5-alkynyl alcohol derivatives were synthesized, and they were cyclized to imidazo-1,4-oxazines by means of cesium carbonate. Propargyl-allene isomerization was examined, and the reaction mechanism was proposed. Moreover, cytotoxicity of synthesized molecules against LN405 cell lines was investigated by means of structure-activity relationship (SAR). With SAR study, toxicities of some functional groups have been shown. In addition, two lead compounds were tested against DNA damaging.