An easy synthetic protocol for imidazo-1,4-oxazines and evaluation of their toxicities


Kuzu B. , Genç H. , Taspinar M. , Tan M. , Mengeş N.

HETEROATOM CHEMISTRY, cilt.29, 2018 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 29 Konu: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1002/hc.21412
  • Dergi Adı: HETEROATOM CHEMISTRY

Özet

Imidazo-1,5-alkynyl alcohol derivatives were synthesized, and they were cyclized to imidazo-1,4-oxazines by means of cesium carbonate. Propargyl-allene isomerization was examined, and the reaction mechanism was proposed. Moreover, cytotoxicity of synthesized molecules against LN405 cell lines was investigated by means of structure-activity relationship (SAR). With SAR study, toxicities of some functional groups have been shown. In addition, two lead compounds were tested against DNA damaging.