First electroanalytical investigation and simple quantification of a thrombopoietin-receptor agonist drug eltrombopag in the presence of cationic surfactant at a non-modified boron-doped diamond electrode


Allahverdiyeva S., Çalışır M., Keskin E., Yardım Y., Şentürk Z.

DIAMOND AND RELATED MATERIALS, cilt.110, 2020 (SCI İndekslerine Giren Dergi) identifier identifier

Özet

The present study describes the first electroanalytical investigation and the development of a novel voltammetric method for a sensitive, simple, fast, cheap and eco-friendly determination of eltrombopag (ELT). At a borondoped diamond electrode pretreated electrochemically (anodic and subsequent cathodic), the compound presented one or two oxidation steps at relatively low positive potentials within the pH range 6.0-12.0 by employing square-wave voltammetry. The sensitivity of the measurements was significantly enhanced with the positive effect of cetyltrimethylammonium bromide (CTAB) under the accumulation condition. In Britton-Robinson buffer pH 12.0 containing 2 x 10(-4) mol L-1 CTAB (after 30 s accumulation at open-circuit condition), there was a linear dependence of peak current at +0.19 V (vs. Ag/AgCl) and ELT concentration in the range of 0.1-12.5 mu g mL(-1) (2.3 x 10(-7)-2.8 x 10(-5) mol L-1) with a detection limit of 0.0125 mu g mL(-1) (5.7 x 10(-8) mol L-1). The developed approach could be used for ELT determination in commercial tablet formulations.