A Network Toxicology Analysis of the Molecular Pathways and Novel Targets in TCDD-Induced Cardiovascular Toxicity TCDD ile Indöklenen Kardiyovasköler Toksisitede Moleköler Yolaklarin ve Yeni Hedeflerin Aǧ Toksikolojisi Analizi

Karakuş F.

Fabad Journal of Pharmaceutical Sciences, vol.49, no.2, pp.359-370, 2024 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 2
  • Publication Date: 2024
  • Doi Number: 10.55262/fabadeczacilik.1471982
  • Journal Name: Fabad Journal of Pharmaceutical Sciences
  • Journal Indexes: Scopus, EMBASE, International Pharmaceutical Abstracts, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.359-370
  • Keywords: Cardiovascular toxicity, Hsa-miR-125b-5p, Hsa-miR-19a-3p, NFKB1, TCDD.
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), an environmental contaminant, disrupts multiple systems including endocrine, immun, nervous, reproductive, developmental, and cardiovascular. This study aimed to identify the molecular pathways and potential therapeutic targets for TCDD-induced cardiovascular toxicity using CTD, ShinyGO, STRING, GeneMANIA, ChEA3, MIENTURNET, and Cytoscape computational tools. The analysis identified the AGERAGE signaling pathway, blood circulation, and cytokine receptor binding as the top 3 among ten key molecular pathways, biological processes, and molecular functions associated with TCDD-induced cardiovascular toxicity. Additionally, ten hub proteins/genes were found to play a critical role, with NFKB1 being the most essential regulating transcription factor and hsa-miR-19a-3p and hsa-miR-125b-5p as the most crucial microRNAs. This study sheds light on the molecular mechanisms underlying TCDD-induced cardiovascular toxicity, revealing novel potential targets for therapeutic intervention.