Voltammetric Investigation of Antiviral Drug Valacyclovir at a Boron-Doped Diamond Electrode in Different Electrolyte Media: Its Determination Enhanced by Anionic Surfactant in Pharmaceuticals and Biological Fluids

Talay Pınar P., Şentürk Z.

CURRENT PHARMACEUTICAL ANALYSIS, vol.13, no.2, pp.175-187, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.2174/1573412912666160901102844
  • Journal Name: CURRENT PHARMACEUTICAL ANALYSIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.175-187
  • Keywords: Valacyclovir, boron-doped diamond electrode, sodium dodecylsulfate, tablet, biological samples, ADSORPTIVE STRIPPING VOLTAMMETRY, GLASSY-CARBON ELECTRODE, ELECTROCHEMICAL-BEHAVIOR, SQUARE-WAVE, SENSITIVE DETECTION, GRAPHITE ELECTRODE, CHLOROGENIC ACID, HPLC METHOD, OXIDATION, ACYCLOVIR
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

Background: The electrochemical oxidation of antiviral drug valacyclovir was first investigated in aqueous and aqueous/surfactant solutions by cyclic and linear sweep voltammetry using a borondoped diamond electrode. The compound was oxidized in one, two or three steps at high positive potentials, depending on pH and composition of the supporting electrolyte, scan rate and surfactant type.