Serum nesfatin-1 levels are decreased in pregnant women newly diagnosed with gestational diabetes


Ademoglu E. N. , Gorar S., Keskin M., Carlioglu A., Ucler R. , Erdamar H., ...Daha Fazla

ARCHIVES OF ENDOCRINOLOGY METABOLISM, cilt.61, ss.455-459, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 61 Konu: 5
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1590/2359-3997000000288
  • Dergi Adı: ARCHIVES OF ENDOCRINOLOGY METABOLISM
  • Sayfa Sayıları: ss.455-459

Özet

Objective: To investigate serum nesfatin-1 levels at 24-28 weeks of pregnancy in women newly diagnosed with gestational diabetes and determine the association of nesfatin-1 with several metabolic parameters. Subjects and methods: Forty women newly diagnosed with gestational diabetes at 24-28 weeks of pregnancy and 30 healthy pregnant women matched in age and gestational week were included in this cross-sectional study. Serum nesfatin-1 levels were analyzed using ELISA, and the relationship between nesfatin-1 and several metabolic parameters were assessed. Results: Serum nesfatin-1 levels were found to be lower in women with gestational diabetes compared to the pregnant women in the control sample (p = 0.020). Multiple linear regression analysis revealed that nesfatin-1 was lower in participants with gestational diabetes independently from gestational age, BMI, HOMA-IR, fasting plasma glucose, and age. In correlation analysis, the only variable that was found to have a statistically significant correlation with nesfatin-1 was gestational age (p = 0.015, r = 0.30). Conclusion: Lower nesfatin-1 levels in women with gestational diabetes compared to the control group at 24-28 weeks of gestation draws attention to nesfatin-1 levels in gestational diabetes and motivates further research in this area.