Clinical Staging, Histopathological Features and Treatment Outcomes in Malignant Melanoma: A 10-Year Retrospective Single-Center Study
Journal of B.U.ON., cilt.28, sa.1, ss.7-15, 2025 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 1
- Basım Tarihi: 2025
- Doi Numarası: 10.5530/jbuon.20250033
- Dergi Adı: Journal of B.U.ON.
- Derginin Tarandığı İndeksler: Scopus, CAB Abstracts
- Sayfa Sayıları: ss.7-15
- Anahtar Kelimeler: Clinical Staging, Histopathology, Malignant Melanoma, Survival, Treatment
- Van Yüzüncü Yıl Üniversitesi Adresli: Evet
Özet
Objectives: We aimed to retrospectively evaluate the clinical stage at diagnosis, histopathological features and treatment outcomes of adult patients with malignant melanoma over a 10-year period at Van YüzüncüYıl University Hospital. Materials and Methods: We reviewed 95 adult patients diagnosed between January 2010 and December 2019. Collected data included demographics, melanoma subtypes, tumor location, AJCC stage, treatment approaches and survival outcomes. Results: The cohort consisted of 52.6% males and 47.4% females, with a mean age of 56.9±16.4 years. Cutaneous melanoma was the most common subtype (81.1%), with nodular melanoma as the predominant histological type. Lesion location significantly affected survival (*p*<0.05). Stage IV was the most frequent at diagnosis (43.2%). Interferon and chemotherapy were common adjuvant therapies. All ocular melanoma cases underwent surgical enucleation. The median follow-up was 24.4 months. Median overall survival was 11.3 months; the 5-year survival rate was 63.6%. Conclusion: Our findings emphasize the prognostic impact of histological subtype, tumor site and disease stage at diagnosis. Expanded access to novel therapies may improve outcomes in this patient population.