The in vivo and in vitro comparative nephrotoxicity of cefazolin and gentamicin


Yilmaz O. , CABALAR M., OZBILGIN S.

VETERINARY AND HUMAN TOXICOLOGY, cilt.41, ss.222-225, 1999 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 41 Konu: 4
  • Basım Tarihi: 1999
  • Dergi Adı: VETERINARY AND HUMAN TOXICOLOGY
  • Sayfa Sayıları: ss.222-225

Özet

Biochemical, histopathological and cell culture evaluations compared the nephrotoxicity of cefazolin with that of gentamicin. New Zealand rabbits were dosed with 250 mg cefazolin/animal im twice daily, 3 mg gentamicin/kg im twice daily, or 0.9% NaCl solution for 10 d. The rabbits in drug-treated groups had necrosis of proximal kidney tubules and elevated urinary-gamma glutamyl transferase (uGGT) levels. The results of the histopathological examinations, uGGT analyses and effects in cell culture indicated the nephrotoxicities of both antibiotics were similar.