Isoquinoline-substituted triazole and pyran derivatives: synthesis and computational studies


Yenidede D., Gümüş S. , Gümüş A.

TURKISH JOURNAL OF CHEMISTRY, vol.40, no.4, pp.655-666, 2016 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.3906/kim-1512-31
  • Title of Journal : TURKISH JOURNAL OF CHEMISTRY
  • Page Numbers: pp.655-666

Abstract

The one-pot synthesis of novel 1,4-disubstituted 1,2,3-triazoles from isoquinoline-substituted homopropargyl alcohol backbone is described (42%-88% yields). A ring closing metathesis reaction and an intramolecular Pauson-Khand reaction of enyne system derived from a homopropargyl alcohol backbone to afford the corresponding isoquinoline-substituted dihydropyran and cyclopentenone-pyran, respectively, are also described (54% and 78% yields). Information about the structural, electronic, and physico-chemical properties of the novel compounds, obtained by density functional theory application, is also reported.