Isoquinoline-substituted triazole and pyran derivatives: synthesis and computational studies


Yenidede D., Gümüş S. , Gümüş A.

TURKISH JOURNAL OF CHEMISTRY, cilt.40, ss.655-666, 2016 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 40 Konu: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3906/kim-1512-31
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Sayfa Sayıları: ss.655-666

Özet

The one-pot synthesis of novel 1,4-disubstituted 1,2,3-triazoles from isoquinoline-substituted homopropargyl alcohol backbone is described (42%-88% yields). A ring closing metathesis reaction and an intramolecular Pauson-Khand reaction of enyne system derived from a homopropargyl alcohol backbone to afford the corresponding isoquinoline-substituted dihydropyran and cyclopentenone-pyran, respectively, are also described (54% and 78% yields). Information about the structural, electronic, and physico-chemical properties of the novel compounds, obtained by density functional theory application, is also reported.