Electrochemical Determination of Anti-Cancer Drug Dabrafenib with High Sensitivity Using Multi-Walled Carbon Nano Tubes Modified Glassy Carbon Electrode

Mete C., Talay Pınar P.

ChemistrySelect, cilt.9, sa.23, 2024 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 23
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1002/slct.202401446
  • Dergi Adı: ChemistrySelect
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
  • Anahtar Kelimeler: Dabrafenib, electrochemical determination, human serum sample, multi-walled carbon nanotube, voltammetric sensor
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

Dabrafenib (DAB) is an organofluor compound and a protein kinase inhibitor used as the mesylate salt in the treatment of metastatic melanoma. For the first time, the electrochemical investigation of the anticancer drug DAB in human serum was conducted using a glassy carbon electrode modified with multi-walled carbon nanotubes (MWCNTs), employing cyclic voltammetry and square wave voltammetry (SWV) techniques. Electrochemical impedance spectroscopy, cyclic voltammetry, and scanning electron microscopy (SEM) techniques were utilized to analyze the surface morphology and structure of the MWCNT/GC electrode. In the proposed method using optimized experimental conditions, two different linearities were obtained for DAB in the concentration range of 0.04–0.8 μM and 1.0–10.0 μM. The LOD value obtained is 0.014 μM. In this study, the resulting electrochemical sensor was applied for the first time to investigate the electrochemical behavior of DAB with high sensitivity and reproducibility, as well as the possible electrochemical oxidation mechanism.