Objective: Immune thrombocytopenia (ITP) is the most common cause of thrombocytopenia. Two-thirds of the cases respond to first-line therapy with corticosteroids. However, there is a 50% relapse rate six months after the treatment. Information predicting recurrence at the time of the diagnosis is limited. This study aimed to investigate the relationship of mean platelet volume (MPV) and the neutrophil/lymphocyte ratio (NLR) at the time of the diagnosis with ITP recurrence. Methods: The study included 171 adult primary ITP patients who received corticosteroids and/or intravenous immunoglobulin (IVIG) as first-line therapy. The relationship between the demographic characteristics of the patients and the laboratory values at the time of the diagnosis with the frequency of recurrence was evaluated. Results: A total of 126 (73.7%) female and 45 (26.3%) male patients with a mean age of 38.54 +/- 17.41 years were included in the study. 89 (52%) patients had a recurrence after first-line therapy. No relationship was found between the frequency of recurrence and age, gender, the presence of comorbid diseases, bleeding status, type of the first-line treatment, CRP, and MPV values. However, there was a statistically significant relationship between NLR increase and the frequency of recurrence (P=0.049). Conclusion: In this study, an association was found between the NLR levels and the rate of recurrence in ITP patients receivingfirst-line treatment. Further studies with larger sample sizes are needed to support this finding.