Phytochemical Investigation of Leontice leontopetalum L. subsp ewersmannii with Antioxidant and Anticholinesterase Activities


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KOLAK U., Hacibekiroglu I., Boga M., Özgökçe F., Ünal M., CHOUDHARY M. I. , ...More

RECORDS OF NATURAL PRODUCTS, vol.5, no.4, pp.309-313, 2011 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 5 Issue: 4
  • Publication Date: 2011
  • Journal Name: RECORDS OF NATURAL PRODUCTS
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.309-313
  • Keywords: Leontice leontopetalum L. subsp ewersmannii, Berberidaceae, lupanine, anticholinesterase, ALKALOIDS

Abstract

Abstract:

wo known quinolizidine alkaloids, lupanine and leontiformidine, were isolated from the tubers of L. leontopetalum subsp. ewersmannii. Lupanine having the highest inhibition of lipid peroxidation at 100 μg/mL among the tested samples indicated almost the same ABTS cation radical scavenging activity with BHT, a- tocopherol and (+)-catechin at the same concentration. Lupanine and the alkaloidal extract showed almost the same butyrylcholinesterase inhibitory activity with galantamine at 200 μg/mL.
Keywords: Leontice leontopetalum L. subsp. ewersmannii; Berberidaceae; lupanine; anticholinesterase.

Two known quinolizidine alkaloids, lupanine and leontiformidine, were isolated from the tubers of L. leontopetalum subsp. ewersmannii. Lupanine having the highest inhibition of lipid peroxidation at 100 mu g/mL among the tested samples indicated almost the same ABTS cation radical scavenging activity with BHT, alpha-tocopherol and (+)-catechin at the same concentration. Lupanine and the alkaloidal extract showed almost the same butyrylcholinesterase inhibitory activity with galantamine at 200 mu g/mL.