Phytochemical Investigation of Leontice leontopetalum L. subsp ewersmannii with Antioxidant and Anticholinesterase Activities

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KOLAK U., Hacibekiroglu I., Boga M., Özgökçe F., Ünal M., CHOUDHARY M. I., ...Daha Fazla

RECORDS OF NATURAL PRODUCTS, cilt.5, sa.4, ss.309-313, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 5 Sayı: 4
  • Basım Tarihi: 2011
  • Dergi Adı: RECORDS OF NATURAL PRODUCTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.309-313
  • Anahtar Kelimeler: Leontice leontopetalum L. subsp ewersmannii, Berberidaceae, lupanine, anticholinesterase, ALKALOIDS
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

Two known quinolizidine alkaloids, lupanine and leontiformidine, were isolated from the tubers of L. leontopetalum subsp. ewersmannii. Lupanine having the highest inhibition of lipid peroxidation at 100 mu g/mL among the tested samples indicated almost the same ABTS cation radical scavenging activity with BHT, alpha-tocopherol and (+)-catechin at the same concentration. Lupanine and the alkaloidal extract showed almost the same butyrylcholinesterase inhibitory activity with galantamine at 200 mu g/mL.

Abstract:

wo known quinolizidine alkaloids, lupanine and leontiformidine, were isolated from the tubers of L. leontopetalum subsp. ewersmannii. Lupanine having the highest inhibition of lipid peroxidation at 100 μg/mL among the tested samples indicated almost the same ABTS cation radical scavenging activity with BHT, a- tocopherol and (+)-catechin at the same concentration. Lupanine and the alkaloidal extract showed almost the same butyrylcholinesterase inhibitory activity with galantamine at 200 μg/mL.
Keywords: Leontice leontopetalum L. subsp. ewersmannii; Berberidaceae; lupanine; anticholinesterase.