Studies on DNA Interaction with 2(3),9(10), 16(17), 23(24)-Tetrakis 2((4-Phenoxyphenyl) Diazeylbenzoic acid)phthalocyaninato Zinc (II) Compound


ARSLANTAŞ A., Ağırtaş M. S.

CHEMISTRYSELECT, vol.3, no.6, pp.1755-1760, 2018 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 3 Issue: 6
  • Publication Date: 2018
  • Doi Number: 10.1002/slct.201800172
  • Title of Journal : CHEMISTRYSELECT
  • Page Numbers: pp.1755-1760

Abstract

In this study, 2(3), 9(10), 16(17), 23(24)-tetrakis 2((4-phenoxyphenyl) diazeylbenzoic acid)phthalocyaninato zinc (II) compound was chosen to study DNA binding activities. The binding activities of zinc (II) phthalocyanine compound bearing 2(3),9(10), 16(17), 23(24)-tetrakis 2((4-Phenoxyphenyl) diazeylbenzoic acid) ligand with Calf Thymus (CT)-DNA was investigated using absorption titration, fluorescence spectroscopy, cyclic voltammetry and thermal melting profile in a Tris-HCl buffer system at pH7.0. In addition to these methods, gel electrophoresis and viscosity measurements were also carried out to determine DNA binding activities with compound 6 in a buffer solution. The results indicated that compound 6 interacts with CT-DNA through partial intercalation binding mode.