Experimental study of in-vitro bioanalysis and in-vivo living tissue biocompatibility of Mg–Zn alloys

Comba B., Cicek B., Comba A., SANCAK T., Akveran G. A., Koc E., ...More

Journal of Materials Research, vol.38, no.8, pp.2203-2212, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 8
  • Publication Date: 2023
  • Doi Number: 10.1557/s43578-023-00950-w
  • Journal Name: Journal of Materials Research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, ABI/INFORM, Aerospace Database, Applied Science & Technology Source, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • Page Numbers: pp.2203-2212
  • Keywords: Albino rat, Biocorrosion, Biomaterial, Mg alloys, Tissue implant
  • Van Yüzüncü Yıl University Affiliated: Yes


In this study in-vitro bioanalysis and in-vivo living tissue biocompatibility were evaluated. Pure Mg and Mg + x Zn (x = 1 and 3 wt%) alloys have been used in the study. In vitro immersion and potentiodynamic corrosion were applied to these alloys in Hank’s and artificial seawater solution. The materials were kept in living tissue (gluteus-superficial) for 7 weeks in-vivo (albino-rat). After 4 and 7 week, the control and experimental groups’ urine parameters, blood mineral substance levels, and radiographic image controls were evaluated. It was observed that the bio-dissolution level decreased as the Zn-ratio increased. As a result, successful results were obtained in the biocompatible and biodegradable material class of Zn-doped Mg alloys used in the study. The dissolution amount of 1.03 mm/y (for Mg + 3Zn alloy) in Hank’s solution was calculated. The % vitality was determined at the level of 117%. Graphical abstract: [Figure not available: see fulltext.]