MEDICAL SCIENCE, vol.26, pp.1-11, 2022 (ESCI)
This research; the effects of omega-3 fatty acids and exercise on irisin, leptin
and ghrelin hormone total cholesterol, HDL, LDL and triglyceride levels when
applied separately or in combination were investigated. Method; A total of 28
male Wistar albino rats, 8 weeks old, were randomly divided into 4 groups of
seven each as control, exercise, omega (400 mg/kg) and exercise + omega-3.
After starting the omega-3 fatty acid diet, rats were subjected to a 20-minute
jog test 5 days a week for 10 weeks. Results; It was determined that exercise
and omega-3 supplementation decreased the total cholesterol level in the
groups in which they were applied separately, and increased the total
cholesterol level when they were applied together. When we examined the
triglyceride levels, it was determined that while there was an increase in the
exercise group, there was a decrease in the omega group, and when the
exercise and omega-3 supplementation were combined, it decreased similarly
to the omega group. In addition, when we examined HDL and LDL
cholesterol levels, it was found that exercise and omega-3 fatty acids increased
HDL levels separately and in combination, LDL levels decreased in omega-3
and exercise groups, but there was no change in cholesterol levels.
Conclusion; positive effects of exercise on lipid profile and iris, moderate
positive correlation between irisin and leptin; It can be said that irisin and
ghrelin show a highly positive relationship and omega-3 fatty acids have
positive effects on the lipid profile.