Akademik Veri Yönetim Sistemi
5th European Conference on Metal Organic Frameworks and Porous Polymers, Granada, İspanya, 24 - 27 Eylül 2023, ss.100
Over the last two decades, metal-organic frameworks (MOFs) nanoparticles have received extensive attention as effcient carriers in drug, nucleic acid, protein and gene delivery applications owing to their well-defned crystalline porous structures, high loading capacity-controlled release, low toxicity and easy chemical functionalization.[1] However, the main drawbacks of using MOFs as drug delivery system (DDS) is normally their stability in biological milieus and the bioavailability, effcacy, and control pharmacokinetics/dynamics of their cargo. Moreover, few studies have investigated the effect on the biodistribution/bioaccumulation, biocompatibility, release kinetics of the cargo, and biodegradability of
the MOF carrier.[2]
Here, we present the synthesis of a novel DDS based on the combination of the zeolitic imidazole framework-8 MOF (ZIF-8) and lipid molecules. In our strategy, self-assembled lipids in the form of vesicles (lipid monolayer) or liposomes (lipid bilayer) are used as platforms for the encapsulation of either hydrophobic or hydrophilic actives into ZIF-8 particles during its synthesis process. By means of this strategy, for example, Astaxanthin –a potent water-insoluble and unstable antioxidant with antiproliferative, neuroprotective, and anti-inflammatory activity- have been encapsulated into LipidZIF-8 nanoparticles with a high encapsulation yield. The resulting DDS shows a good antioxidant capacity and an improved colloidal stability in biological milieus. Astaxanthin gastrointestinal digestion has been also evaluated according to the INFOGEST 2.0 static in vitro simulation protocol. Likewise, our
strategy using lipids have also enabled to functionalize ZIF-8 with fluorescent molecules such as Nile Red fluorophore; modulate the surface charge of ZIF-8 particles; and enhance the capture of metals in water using phenolic lipids.