Akademik Veri Yönetim Sistemi
5th European Conference on Metal Organic Frameworks and Porous Polymers, Granada, İspanya, 24 - 27 Eylül 2023, ss.1-644
Over the last two decades, metal-organic frameworks (MOFs) nanoparticles have received extensive
attention as effcient carriers in drug, nucleic acid, protein and gene delivery applications owing to
their well-defned crystalline porous structures, high loading capacity-controlled release, low toxicity
and easy chemical functionalization.[1] However, the main drawbacks of using MOFs as drug delivery
system (DDS) is normally their stability in biological milieus and the bioavailability, effcacy, and control
pharmacokinetics/dynamics of their cargo. Moreover, few studies have investigated the effect on the
biodistribution/bioaccumulation, biocompatibility, release kinetics of the cargo, and biodegradability of
the MOF carrier.[2]
Here, we present the synthesis of a novel DDS based on the combination of the zeolitic imidazole
framework-8 MOF (ZIF-8) and lipid molecules. In our strategy, self-assembled lipids in the form of
vesicles (lipid monolayer) or liposomes (lipid bilayer) are used as platforms for the encapsulation of
either hydrophobic or hydrophilic actives into ZIF-8 particles during its synthesis process. By means
of this strategy, for example, Astaxanthin –a potent water-insoluble and unstable antioxidant with
antiproliferative, neuroprotective, and anti-inflammatory activity- have been encapsulated into LipidZIF-8 nanoparticles with a high encapsulation yield. The resulting DDS shows a good antioxidant
capacity and an improved colloidal stability in biological milieus. Astaxanthin gastrointestinal digestion
has been also evaluated according to the INFOGEST 2.0 static in vitro simulation protocol. Likewise, our
strategy using lipids have also enabled to functionalize ZIF-8 with fluorescent molecules such as Nile
Red fluorophore; modulate the surface charge of ZIF-8 particles; and enhance the capture of metals in
water using phenolic lipids.