Do cardiac neuropeptides play a role in the occurrence of atrial fibrillation after coronary bypass surgery?

Guler N., Ozkara C., Dulger H., Kutay V., Sahin M., Erbilen E., ...More

ANNALS OF THORACIC SURGERY, vol.83, no.2, pp.532-537, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 83 Issue: 2
  • Publication Date: 2007
  • Doi Number: 10.1016/j.athoracsur.2006.08.040
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.532-537
  • Van Yüzüncü Yıl University Affiliated: Yes


Background. One of the potential mechanisms to explain the occurrence of postoperative atrial fibrillation (AF) is imbalance of autonomic nervous system tone. The myocardium is innervated not only by cholinergic and adrenergic nerves but also by peptidergic nerves that synthesize and secrete neuropeptides. To investigate the possible role of cardiac neuropeptides in the development of AF after coronary artery bypass grafting (CABG), we analyzed the plasma levels of substance P (SubP), neuropeptide Y (NPY), and angiotensin II (Ang II) in patients who underwent elective on-pump CABG.