Protective role of methanol extracts of two lichens on oxidative and genotoxic damage caused by AFB(1) in human lymphocytes in vitro

Aslan A., AĞAR G., Alpsoy L., Kotan E., Ceker S.

TOXICOLOGY AND INDUSTRIAL HEALTH, vol.28, no.6, pp.505-512, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 6
  • Publication Date: 2012
  • Doi Number: 10.1177/0748233711416944
  • Journal Name: TOXICOLOGY AND INDUSTRIAL HEALTH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.505-512
  • Van Yüzüncü Yıl University Affiliated: No

Abstract

In this study, the antigenotoxic and antioxidant effects of Umbilicaria vellea (UME) and Xantho somloensis (XME) extracts were determined using sister chromatid exchange (SCE), micronuclei (MN) assays, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and malondialdehyde (MDA) levels against the effects of aflatoxin B-1 (AFB(1))-induced oxidative stress and genotoxicity in human lymphocytes in vitro. The results showed that the frequencies of SCE, MN, and MDA level decreased, but the activities of SOD and GPx increased when 5 mu g/mL and 10 mu g/mL doses of UME and XME were added to AFB(1)-treated cultures. Also the present results indicate that strong antioxidative and the antigenotoxicity mechanisms of UME and XME are associated with its antioxidant nature.