Acetaminophen intoxication is associated with decreased serum paraoxonase and arylesterase activities and increased lipid hydroperoxide levels

KARADAS S., Aslan M., GONULLU H. , Kati C., Duran L., OLMEZ S. , ...Daha Fazla

HUMAN & EXPERIMENTAL TOXICOLOGY, cilt.33, sa.11, ss.1134-1140, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 33 Konu: 11
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1177/0960327113511477
  • Sayfa Sayıları: ss.1134-1140


Background: Acetaminophen is at present one of the most commonly used analgesics and antipyretics. Recent evidence has suggested that oxidative stress is involved in the mechanism of acetaminophen intoxication. Paraoxonase-1 (PON1) plays an important role as an endogenous free-radical scavenging molecule. The aim of this study was to evaluate the influence of serum PON1 activity and oxidative stress in patients with acetaminophen intoxication.