Acetaminophen intoxication is associated with decreased serum paraoxonase and arylesterase activities and increased lipid hydroperoxide levels

KARADAS S., Aslan M., GONULLU H., Kati C., Duran L., OLMEZ S., ...More

HUMAN & EXPERIMENTAL TOXICOLOGY, vol.33, no.11, pp.1134-1140, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 11
  • Publication Date: 2014
  • Doi Number: 10.1177/0960327113511477
  • Journal Name: HUMAN & EXPERIMENTAL TOXICOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1134-1140
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

Background: Acetaminophen is at present one of the most commonly used analgesics and antipyretics. Recent evidence has suggested that oxidative stress is involved in the mechanism of acetaminophen intoxication. Paraoxonase-1 (PON1) plays an important role as an endogenous free-radical scavenging molecule. The aim of this study was to evaluate the influence of serum PON1 activity and oxidative stress in patients with acetaminophen intoxication.