Acetaminophen intoxication is associated with decreased serum paraoxonase and arylesterase activities and increased lipid hydroperoxide levels
HUMAN & EXPERIMENTAL TOXICOLOGY, cilt.33, sa.11, ss.1134-1140, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 33 Sayı: 11
- Basım Tarihi: 2014
- Doi Numarası: 10.1177/0960327113511477
- Dergi Adı: HUMAN & EXPERIMENTAL TOXICOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1134-1140
- Van Yüzüncü Yıl Üniversitesi Adresli: Evet
Özet
Background: Acetaminophen is at present one of the most commonly used analgesics and antipyretics. Recent evidence has suggested that oxidative stress is involved in the mechanism of acetaminophen intoxication. Paraoxonase-1 (PON1) plays an important role as an endogenous free-radical scavenging molecule. The aim of this study was to evaluate the influence of serum PON1 activity and oxidative stress in patients with acetaminophen intoxication.