Anaplasma phagocytophilum in Horses - Evaluation of Proinflammatory Biomarkers

Mis L., Oğuz B.

ACTA SCIENTIAE VETERINARIAE, vol.50, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 50
  • Publication Date: 2022
  • Doi Number: 10.22456/1679-9216.119981
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, Food Science & Technology Abstracts
  • Keywords: anaplasmosis, EGA, tick-borne pathogens, pro-inflammatory cytokine, antioksidant, oxidative/nitrosative stress, equine, OXIDATIVE STRESS, NITRIC-OXIDE, CYTOKINE, PATHOGENESIS, PARASITEMIA, EXPRESSION, ANION
  • Van Yüzüncü Yıl University Affiliated: Yes


Background: Anaplasma phagocytophilum is an obligate intracellular pathogen transmitted by the ticks that cause equine granulocytic anaplasmosis (EGA). This pathogen is infects predominantly blood cells, principally granulocytes and especially neutrophils. A. phagocytophilum causes an acute febrile disease in horses accompanying with lethargy, loss of appetite, lameness and hemorrhages. In horses, this disease should be considered in all acute symptoms accompanied by thrombocytopenia and leukopenia identified by hematological test performed. Tick-borne pathogens have become increasingly threatening for both animals and also public health since ticks mostly carry numerous well-documented and undocumented pathogens, and the geographical range of ticks has expanded in the recent years. This research has aimed to evaluate the impact of A. phagocytophilum infection on some oxidative/nitrosative stress parameters, antioxidant enzyme activities, proinflammatory biomarkers and trace element levels in horses.