The study compared the influence of Tarantula cubensis extract 1:100/D2 (Theranekron (R), Richter Pharma, Austria) and classic treatment (daily injection of fluniksin meglumin., oxytetracycline, washing the mucosa and feet lesions with 10% sodium bicarbonate and antibiotic spray for 3 consecutive days) for the oral, hoof and mammary lesions treatment in foot and mouth disease in cattle. Ninety mixed breed cattle with foot and mouth diseases were used. Clinical symptoms included fever inappetance oral, hoof and mammary lesions. The cattle were divided into three groups. The first group, the second and the third were treated with classic, theranekron and theranekron plus classic treatments respectively. About 48 h after theranekron and theranekron plus classical application, recovery occurred and body temperature, appetence returned to normal more rapidly than that of the group on which only classical treatment methods were used.