Silent stroke in a case of beta-thalassemia major associated with chronic renal failure and diabetes mellitus


Caksen H., Odabas D., Akbayram S., Oner A., Arslan S., Cesur Y., ...Daha Fazla

JOURNAL OF CHILD NEUROLOGY, cilt.18, sa.11, ss.798-800, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 18 Konu: 11
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1177/08830738030180110201
  • Dergi Adı: JOURNAL OF CHILD NEUROLOGY
  • Sayfa Sayıları: ss.798-800

Özet

Severe anemia, growth retardation, diabetes mellitus, cardiac disorders, and, infrequently, stroke are well-known complications of thalassemia major. We report a girl, age 7 years, 2 months, with beta-thalassemia major associated with chronic renal failure, diabetes mellitus, and cardiomyopathy in whom a silent stroke was noted during follow-up. She was diagnosed with thalassemia major at age 6 months, chronic renal failure at age 3 years, 3 months, and diabetes mellitus and cardiomyopathy at age 7 years. Although cranial computed tomography was found to be normal at the age of 3 years, 3 months, magnetic resonance imaging showed cerebral infarct in the right frontal region at 7 years, 2 months. A thrombophilic panel revealed increased factor VIII and decreased protein C concentrations. She died from disseminated intravascular coagulation at age 7 years, 9 months. We did not record any clinical findings of stroke during her follow-up. We think that diabetes mellitus, dilated cardiomyopathy, and increased factor VIII and decreased protein C concentrations led to the occurrence of cerebral infarct. In conclusion, we emphasize that children with thalassemia major should be monitored closely for stroke. We also suggest that stroke can show a silent progression in severely affected children, as in our case.