TIME-DEPENDENT CHANGES IN PLASMA GHRELIN AND ANGIOTENSIN II LEVELS IN THE DIABETIC NEPHROPATHY MODEL

Gul C., Kelle M., Baylan M., Yokus B., Tasdemir E.

FRESENIUS ENVIRONMENTAL BULLETIN, vol.30, no.1, pp.747-757, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 1
  • Publication Date: 2021
  • Journal Name: FRESENIUS ENVIRONMENTAL BULLETIN
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Aerospace Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, Environment Index, Geobase, Greenfile, Metadex, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Page Numbers: pp.747-757
  • Keywords: Ghrelin, Nephropathy, Angiotensin II, Diabetes, Streptozotocin, BIOLOGICAL-ACTIVITY, ACYLATED PEPTIDE, HYPERTENSION, EXPRESSION, PREVENTION, RECEPTORS, INSULIN, SYSTEM, RATS
  • Van Yüzüncü Yıl University Affiliated: No

Abstract

Ghrelin is an appetite-enhancing anabolic hormone secreted from the stomach. Angiotensin II maintains sodium and potassium levels in body fluids and plays a very important role in the regulation of arterial blood pressure. Although their relationship with Type 2 diabetes and complications have been reported, their role in diabetic nephropathy is not fully understood. We investigated time dependent possible changes in plasma ghrelin and angiotensin II levels during the development and progression of diabetic nephropathy in experimental diabetic rat model. Adult 63 male Wistar Albino rats were randomly divided into 9 groups as 4 control (C1-C4), 4 diabetic (D1-D4) and one treatment (T) group.