FRESENIUS ENVIRONMENTAL BULLETIN, vol.30, no.1, pp.747-757, 2021 (SCI-Expanded)
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FRESENIUS ENVIRONMENTAL BULLETIN
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Ghrelin, Nephropathy, Angiotensin II, Diabetes, Streptozotocin, BIOLOGICAL-ACTIVITY, ACYLATED PEPTIDE, HYPERTENSION, EXPRESSION, PREVENTION, RECEPTORS, INSULIN, SYSTEM, RATS
Van Yüzüncü Yıl University Affiliated:
Ghrelin is an appetite-enhancing anabolic hormone secreted from the stomach. Angiotensin II maintains sodium and potassium levels in body fluids and plays a very important role in the regulation of arterial blood pressure. Although their relationship with Type 2 diabetes and complications have been reported, their role in diabetic nephropathy is not fully understood. We investigated time dependent possible changes in plasma ghrelin and angiotensin II levels during the development and progression of diabetic nephropathy in experimental diabetic rat model. Adult 63 male Wistar Albino rats were randomly divided into 9 groups as 4 control (C1-C4), 4 diabetic (D1-D4) and one treatment (T) group.