Traditional domes are obtained by double curvature shells, which can be rotationally formed by any curved geometrical plane figure rotating about a central vertical axis. They are self-supported and stabilized by the force of gravity acting on their weight to hold them in compression. However, the behavior of inverted domes is different since the dome is downward and masonry inverted domes and their structural behaviors in the literature received limited attention. This article presents a nonlinear finite element analysis of historical brick masonry inverted domes under static and seismic loads. The brick masonry inverted dome in the tomb of scholar Ahmed-El Cezeri, town of Cizre, Turkey, constructed in 1508 is selected as an application. First, a detailed literature review on the masonry domes is given and the selected inverted dome is described briefly. 3D solid and continuum finite element models of the inverted masonry dome are obtained from the surveys. An isotropic Concrete Damage Plasticity (CDP) material model adjusted to masonry structures with the same tensile strength assumed along the parallel and meridian directions of the inverted dome is considered. The nonlinear static analyses and a parametric study by changing the mechanical properties of the brick unit of the inverted masonry dome are performed under gravity loads. The acceleration records of vertical and horizontal components of May 1, 2003 Bingol earthquake (Mw = 6.4), Turkey, occurred near the region, are chosen for the nonlinear seismic analyses. Nonlinear step by step seismic analyses of the inverted dome are implemented under the vertical and horizontal components of the earthquake, separately. Static modal and seismic responses of the inverted masonry dome are evaluated using mode shapes, minimum and maximum principal strains and stresses, and damage propagations.