Properties, Bioactivity, In vitro Drug Release and Functionality as a Biomaterial of Poly(Apigenin) Hydrogel

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Atıf İçin Kopyala

Alpaslan D., Turan A., Erşen Dudu T., Aktaş N.

ADVANCES IN PHARMACOLOGY AND PHARMACY, cilt.13, sa.3, ss.323-332, 2025 (ESCI)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 13 Sayı: 3
• Basım Tarihi: 2025
• Dergi Adı: ADVANCES IN PHARMACOLOGY AND PHARMACY
• Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
• Sayfa Sayıları: ss.323-332
• Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

Abstract Controlled release systems used in the

biomedical industry or still in the animal testing phase

generally use various chemicals, especially natural or

artificial polymers. In recent years, there has been

increasing interest in plant-based products as controlled

release materials. For the first time in the literature,

poly(apigenin) hydrogel was synthesized from apigenin, an

important flavonoid. Swelling percentages and

biodegradation percentages of poly(apigenin) hydrogel at

different pH values were investigated. Structural analyses

of poly(apigenin) hydrogel were performed using FT-IR

(Fourier Transform Infrared Spectroscopy). To examine

drug release amounts and kinetics, different drug active

ingredients (paracetamol, ceftriaxone, and

5-Fluorouracil(5-fu)) were loaded into the poly(apigenin)

hydrogel. The release of paracetamol, ceftriaxone, and 5-fu

from the synthesized poly(apigenin) hydrogel was

determined as 95%, 58% and 96%, (pH 7.4) respectively.

For kinetic studies, zero-order, first-order, Higuchi, and

Korsmeyer-Peppas, models were used. When the

correlation coefficients (R2) were compared, it was seen

that the drug release kinetics fit better with the

Korsmeyer-Peppas model. It was observed that the

poly(apigenin) hydrogel synthesized in this study was a

suitable material for the release systems of paracetamol,

ceftriaxone, and 5-Fluorouracil.