This study, researchers examined the ovariectomy and bilateral molar teetless of mandibular condyle in rat by histologically and histomorphometrically. In this part of the study, 12 Wistar Albino rats, 120 days old and weighing 200-250 g were used. The rats were divided into three groups, a control and two experimental group. The experimental groups of rats were subjected to ovariectomy in. order to create oestrogen deficiency and bilateral molars extraction. After 35 days of ovariectomy, control and experimental group rats were killed and their mandible condyle removed. The speciemens were stained with Hematoxylin and Eosin (HE) and examined for structure of histologically and histomorphometrically. Histomorphometric analysis; mandibular condyle of control and experimental groups were statistically significant results of the histological layers (p<0.05). It was concluded that ovariectomy application and molar teetless can induce histopathological and histomorphometrically changes in the structure of the condyle.