Appraisal of the antimicrobial and cytotoxic potentials of nanoparticles biosynthesized from the extracts of Pelargonium quercetorum Agnew

Dumlupınar B., Şeker Karatoprak G., Fırat M., Akkol E.

FRONTIERS IN BIOSCIENCE-LANDMARK, cilt.26, sa.11, ss.1089-1096, 2021 (SCI-Expanded)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 11
  • Basım Tarihi: 2021
  • Doi Numarası: 10.52586/5011
  • Dergi Adı: FRONTIERS IN BIOSCIENCE-LANDMARK
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.1089-1096
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

Aim: The aim of this study is the synthesis of

nanosilver particles (AgNPs) from Pelargonium quercetorum

Agnew. (Geraniaceae) and evaluation of the antimicrobial

and the cytotoxic potential of AgNPs. Methods:

The synthesized AgNPs were evaluated for antimicrobial

and anticancer efficacy using the minimum inhibition concentration

method and MTT (3-(4,5-Dimethylthiazol-2-yl)-

2,5-Diphenyltetrazolium bromide) assay. Results: The

AgNPs inhibited approximately 90% the growth of grampositive

Staphylococcus aureus and gram-negative Esherichia

coli and yeast Candida albicans pathogens at a concentration

of 500 μg/mL. The synthesized AgNPs showed

excellent toxicity in MCF-7 cells, and specifically, pq70

AgNP inhibited the growth of MCF-7 cells by 52% at a concentration

of 3.125 μg/mL. Conclusion: It was determined

that the AgNPs, which had been synthesized from extracts

that contained a high phenolic composition, were smaller in

size, and showed high anticancer and antimicrobial properties.