Appraisal of the antimicrobial and cytotoxic potentials of nanoparticles biosynthesized from the extracts of Pelargonium quercetorum Agnew


Dumlupınar B., Şeker Karatoprak G., Fırat M., Akkol E.

FRONTIERS IN BIOSCIENCE-LANDMARK, vol.26, no.11, pp.1089-1096, 2021 (Peer-Reviewed Journal)

  • Publication Type: Article / Article
  • Volume: 26 Issue: 11
  • Publication Date: 2021
  • Doi Number: 10.52586/5011
  • Journal Name: FRONTIERS IN BIOSCIENCE-LANDMARK
  • Journal Indexes: Science Citation Index Expanded
  • Page Numbers: pp.1089-1096

Abstract

Aim: The aim of this study is the synthesis of

nanosilver particles (AgNPs) from Pelargonium quercetorum

Agnew. (Geraniaceae) and evaluation of the antimicrobial

and the cytotoxic potential of AgNPs. Methods:

The synthesized AgNPs were evaluated for antimicrobial

and anticancer efficacy using the minimum inhibition concentration

method and MTT (3-(4,5-Dimethylthiazol-2-yl)-

2,5-Diphenyltetrazolium bromide) assay. Results: The

AgNPs inhibited approximately 90% the growth of grampositive

Staphylococcus aureus and gram-negative Esherichia

coli and yeast Candida albicans pathogens at a concentration

of 500 μg/mL. The synthesized AgNPs showed

excellent toxicity in MCF-7 cells, and specifically, pq70

AgNP inhibited the growth of MCF-7 cells by 52% at a concentration

of 3.125 μg/mL. Conclusion: It was determined

that the AgNPs, which had been synthesized from extracts

that contained a high phenolic composition, were smaller in

size, and showed high anticancer and antimicrobial properties.