Synthesis, Antibacterial Activity and Molecular Docking Studies of New Pyrazole Derivatives

Cetin A., Kurt H.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.17, no.6, pp.745-756, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 6
  • Publication Date: 2020
  • Doi Number: 10.2174/1570180816666190905155510
  • Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, EMBASE
  • Page Numbers: pp.745-756
  • Keywords: Binding energy, biologic activity, in silico, ligand efficient, semicarbazide, thiazolidine, BIOLOGICAL EVALUATION, POTENT, 5-CHLORO-3-METHYL-4-NITRO-1H-PYRAZOLE, ABSCISSION, ZONIPORIDE, INHIBITOR, DESIGN
  • Van Yüzüncü Yıl University Affiliated: No

Abstract

Background: The pyrazole structure is an important heterocyclic structure and plays critical roles in agriculture, industrial and medicine. Furthermore, compounds containing pyrazole are known to exhibit various biological properties such as antibacterial, antifungal, anticancer, anti-inflammatory, antidepressant, antipyretic, antiviral, anti-tubercular and anti-HIV activities. Because of these properties, pyrazole molecules have become a very popular topic for organic chemists.