Synthesis, Antibacterial Activity and Molecular Docking Studies of New Pyrazole Derivatives

Cetin A., Kurt H.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.17, sa.6, ss.745-756, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 6
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2174/1570180816666190905155510
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, EMBASE
  • Sayfa Sayıları: ss.745-756
  • Anahtar Kelimeler: Binding energy, biologic activity, in silico, ligand efficient, semicarbazide, thiazolidine, BIOLOGICAL EVALUATION, POTENT, 5-CHLORO-3-METHYL-4-NITRO-1H-PYRAZOLE, ABSCISSION, ZONIPORIDE, INHIBITOR, DESIGN
  • Van Yüzüncü Yıl Üniversitesi Adresli: Hayır

Özet

Background: The pyrazole structure is an important heterocyclic structure and plays critical roles in agriculture, industrial and medicine. Furthermore, compounds containing pyrazole are known to exhibit various biological properties such as antibacterial, antifungal, anticancer, anti-inflammatory, antidepressant, antipyretic, antiviral, anti-tubercular and anti-HIV activities. Because of these properties, pyrazole molecules have become a very popular topic for organic chemists.