The Effects of Exogenous Melatonin on Peripheral Nerve Regeneration and Collagen Formation in Rats


Atik B., ERKUTLU İ., Tercan M., BÜYÜKHATİPOĞLU H., Bekerecioglu M., Pence S.

JOURNAL OF SURGICAL RESEARCH, cilt.166, ss.330-336, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 166 Konu: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.jss.2009.06.002
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Sayfa Sayıları: ss.330-336

Özet

Background. Peripheral nerve damage that requires surgical repair does not result in complete recovery because of collagen scar formation, ischemia, free oxygen radical damage, and other factors. To date, the best treatment method has not yet been determined. In this study, we designed an experimental peripheral nerve injury model, and researched the possible effects of melatonin hormone, based on evidence of its strong antioxidant and cell-protective effects via mimicking the effects of calcium channel blockers.