Akademik Veri Yönetim Sistemi
7th INTERNATIONAL ANTALYA CONGRESS OF SCIENTIFIC RESEARCH AND INNOVATIVE STUDIES, Antalya, Türkiye, 11 - 13 Mayıs 2024, ss.749-755
Introduction and Purpose: Cancer, one of the leading diseases, caused and continues to
cause approximately 10 million deaths worldwide in 2020. Treatment of cancer includes
surgery, chemotherapy, radiotherapy, immunotherapy and others; While these have a huge
economic impact on patients, over time patients develop drug resistance. 30-50% of cancers
can be prevented or treated by implementing evidence-based preventive strategies. Vinca
alkaloids, plant-based drugs, represent one of the oldest classes of antineoplastic agents with a
broad spectrum of activity that has proven efficacy and acceptability in cancer treatment.
Vinblastine, Vincristine, Vindesine, Vinorelbine and Vinflunine are important vinca alkaloids.
Compared to other vinca alkaloids, vinflunine has been shown to have superior efficacy and
an improved safety profile in both in vitro and in vivo studies.In this work,
Materials and Methods: μρ, Zeff, Nel values of vinca alkaloids. were calculated using
WinXCom computer program. WinXCom program calculates photon interaction crosssections
and attenuation coefficients for any element, compound or mixture, at energies from
1 keV to 100 GeV.
Results: According to the data obtained; It has been observed that the photoelectric
absorption effect is dominant at low energies, Compton scattering is dominant at intermediate
energies, and the double generation effect is dominant at high energies.
Conclusion: It is thought that the results obtained in this research may be useful in radiation
dosimetry and treatment.
Keywords: Effective atomic number, Electron density, Mass attenuation coefficient, Vinca
Alkaloids