An anodically pretreated boron-doped diamond electrode surface for square-wave adsorptive stripping voltammetric quantification of the non-absorbable antibiotic rifaximin in the pharmaceutical formulation


Barzani H. A., Ali H. S., Yardım Y.

Diamond and Related Materials, vol.132, 2023 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 132
  • Publication Date: 2023
  • Doi Number: 10.1016/j.diamond.2022.109647
  • Journal Name: Diamond and Related Materials
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Chemical Abstracts Core, Communication Abstracts, INSPEC, Metadex, Civil Engineering Abstracts
  • Keywords: Boron-doped diamond electrode, Pharmaceutical formulation, Rifaximin, Voltammetric determination
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

© 2022 Elsevier B.V.This study presents an electroanalytical examination with the voltammetric technique for quantitatively evaluating rifaximin (RFX) using the non-modified boron-doped diamond (BDD) electrode. By utilizing cyclic voltammetry (CV) method, RFX illustrated only one well-defined, irreversible, adsorption-controlled by oxidation and reduction peak at about +0.64 V and +0.21 V, respectively, (vs Ag/AgCl) in 0.1 M HNO3 solution. The square-wave (SW) voltammetric technique examined the dependence of potentials and current intensities on the BDD electrode pretreatment, the nature of a supporting electrolyte, pH, and another characteristic. When the SW mode was used, a satisfactory linear response was achieved in 0.1 M HNO3 solution at +0.56 V (vs Ag/AgCl). The dynamic range is observed from 0.5 to 20.0 μg mL−1 (6.36 × 10−7–2.54 × 10−5 M) via a low limit of detection of 0.14 μg mL−1 (1.7810−7 M). The applicability of the developed method for detecting RFX was exhibited in pharmaceutical formulation samples.