The Association between Exocrine Pancreatic Dysfunction and Insulin Resistance in an Insulin-Resistant Population in Turkey: A Cross-Sectional Study

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Yıldız S., Sönmez G. M., Kömüroğlu A. U., Alay M.

NIGERIAN JOURNAL OF CLINICAL PRACTICE, vol.26, no.8, pp.1051-1056, 2023 (SCI-Expanded)

  • Publication Type: Article / Article
  • Volume: 26 Issue: 8
  • Publication Date: 2023
  • Doi Number: 10.4103/njcp.njcp_1451_21
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, MEDLINE
  • Page Numbers: pp.1051-1056
  • Van Yüzüncü Yıl University Affiliated: Yes


Background: In insulin resistance (IR), it is thought that pancreatic fat

accumulation may decrease pancreatic volume, cause an impaired endocrine

function, and simultaneously lead to an exocrine dysfunction before diabetes

develops. Aim: The association between pancreatic exocrine function and

insulin resistance (IR) was assessed in a population with insulin resistance.

Method: This was a descriptive cross‑sectional study that included 43 IR cases with

no other comorbid diseases or pregnancy and 41 healthy controls. Fasting blood

adiponectin, leptin, pancreatic amylase, lipase, and stool fecal elastase‑1 (FE‑1)

were studied and compared in both groups. Results: The IR group consisted of

38 females (88.3%) and five males (11.6%), while the control group consisted of

31 females (75.6%) and ten males (24.3%). FE‑1 levels were significantly lower

in the IR group (P-value <0.01). Blood glucose, insulin, and HbA1c levels were

significantly higher in the IR group than in the control (P-value of <0.01, <0.01,

<0.01, respectively). Leptin levels were significantly higher in the IR group

compared to the controls (P-value = 0.013). After dividing the whole group (n:

84) into two groups as FE‑1 <200 μg/g (n: 61) and FE‑1 ≥200 μg/g (n: 23),

logistic regression analysis was performed; the significant predictor of low FE‑1

was HOMA‑IR (ODD ratio: 4.27, P-value <0.01, 95% confidence interval for

ODD ratio: 1.95–9.30). Conclusion: This study showed that IR is associated with

pancreatic exocrine dysfunction.

Keywords: Fecal elastase 1, Insulin resistance, Pancreatic exocrine dysfunction