Histopathological and biochemical investigations of protective role of honey in rats with experimental aflatoxicosis


Yaman T. , Yener Z. , Çelik İ.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, cilt.16, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 16
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1186/s12906-016-1217-7
  • Dergi Adı: BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE

Özet

Background: Natural honey (honey) is considered as a part of traditional medicine all over the world. It has both antimicrobial and antioxidant properties, useful in stimulation of wounds and burns healing and gastric ulcers treatment. The aim of this study, for the first time, was to investigate the antioxidant properties and protective role of honey against carcinogen chemical aflatoxin (AF) exposure in rats, which were evaluated by histopathological changes in liver and kidney, measuring level of serum marker enzymes [aspartate aminotransferase (AST), alanin aminotransferase (ALT), gamma glutamil transpeptidase (GGT)], antioxidant defense systems [Reduced glutathione (GSH), glutathione reductase (GR), superoxide dismutase (SOD), glutathione-S-transferase (GST) and catalase (CAT)], and lipid peroxidation content in liver, erythrocyte, brain, kidney, heart and lungs.